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*Apply to join Foresight Biotech & Health Extension program:* https://foresight.org/focus-areas/longevity-biotechnology/ A group of scientists, entrepreneurs, funders, and institutional allies who cooperate to advance biotechnology to reverse aging and extend human healthspan. This group is sponsored by 100 Plus Capital. http://100pluscap.com/ *Foresights Personal Longevity Group* Exploring anti-aging methods, monthly virtual meetings, expert discussions, private group for Foresight Patrons. https://foresight.org/personal-longevity-group/ *Christopher Bradley | Protecting the Genome* *Harnessing millions of years of evolution to construct DNA stability treatments for longevity and cancer* Abstract: Aging and cancer are both driven by the gradual accumulation of DNA damage, yet nature has already evolved remarkable solutions. Greenland sharks live over 500 years, bowhead whales surpass 200, and human supercentenarians carry protective gene variants that keep their genomes intact for longer. At the same time, bacteria have spent millions of years perfecting ways to infiltrate and manipulate cells, strategies we can now re-engineer for human benefit. By learning from these long-lived species and harnessing synthetically engineered microbes, we are beginning to imagine therapies that could not only cure cancer but also extend healthy human lifespan. www.matter.bio Bio: Christopher Bradley is an entrepreneur and scientist focused on advancing human health and longevity. He is the CEO and Co-Founder of Matter Bio, a biotechnology company developing DNA-preserving gene therapy and synthetic bacterial immune-oncology to extend healthy lifespan by combating DNA damage and cancer. Previously, he co-founded and served as CEO of Mana Health, a health data interoperability company that was later acquired by Comcast, where he went on to lead healthcare product and data initiatives as Executive Director. He has a background in neuroscience, cell biology, and computer science. ══════════════════════════════════════ *About The Foresight Institute* The Foresight Institute is a research organization and non-profit that supports the beneficial development of high-impact technologies. Since our founding in 1986 on a vision of guiding powerful technologies, we have continued to evolve into a many-armed organization that focuses on several fields of science and technology that are too ambitious for legacy institutions to support. From molecular nanotechnology, to brain-computer interfaces, space exploration, cryptocommerce, and AI, Foresight gathers leading minds to advance research and accelerate progress toward flourishing futures. *We are entirely funded by your donations. If you enjoy what we do please consider donating through our donation page:* https://foresight.org/donate/ *Visit* https://foresight.org, *subscribe to our channel for more videos or join us here:* *• Twitter:* https://twitter.com/foresightinst *• Facebook:* https://www.facebook.com/foresightinst *• LinkedIn:* https://www.linkedin.com/company/foresight-institute ══════════════════════════════════════ *Timecodes* 00:00 Introduction and Welcome 00:04 Meet Christopher Bradley and Matter Bio 00:39 The Team and Phase One Trials 01:19 Understanding DNA Damage and Aging 03:30 Preventing and Treating DNA Damage 04:25 Innovative Bacterial Therapy for Cancer 07:26 Exciting Preclinical Data and Future Prospects 09:50 Exploring Longevity and Genome Stability 11:50 Research on Long-Lived Animals and Humans 18:51 Gene Editing and Repair Pathways 22:04 Combining Genes for Maximum Protection 30:03 Future Directions and Delivery Strategies 31:40 Narrowing Down the Problem 31:54 Exploring Treatment Options 32:31 Case Study: Xeroderma Pigmentosum 34:07 Research and Development Updates 35:11 Q&A Session Begins 36:36 Discussion on Gene Therapy and Longevity 40:04 Challenges and Future Directions 47:41 Final Questions and Closing Remarks