Cubane Lore (Cubane Tier List)

Video Description

Use code POGCHEMISTAPR50 for 50% off your first box at https://strms.net/ThatChemistFactorAprYT50 #ad Cubanes are a pretty neat class of molecules – in this video, we explore the applications of cubanes, and rank some impressive cubanes such as BUTTERCUBE! Summary In this, the host discusses Cubane, a cube-shaped molecule, and its potential applications in medicinal chemistry. Cubane is considered as a substitute for Benzene rings in new drug candidates. The 3D structure of Cubane allows for distinct interactions with target proteins or receptors. Additionally, Cubane can have different metabolites compared to Benzene. It is also explored in energetic materials. The video presents a tier list of various Cubane derivatives, highlighting their structures and uniqueness. Highlights 💡 Cubane is a cube-shaped molecule that medicinal chemists want to use as a substitute for Benzene rings in new drug candidates. 💡 Substituting a Benzene ring with Cubane in an active pharmaceutical ingredient (API) could potentially improve binding to the target. 💡 Cubane's 3D structure allows for different interactions in space, unlike the flat Benzene ring. 💡 Cubane derivatives can have different metabolites compared to Benzene, which is important for drug elimination from the body. 💡 Cubane is also explored in energetic materials, although its large-scale production poses challenges. 💡 The tier list of Cubane derivatives ranks them based on their impressive structures, with S tier being the most impressive. 💡 The video acknowledges the need for more commercially available and affordable Cubane derivatives to advance research and drug development. Support the Channel on Patreon - https://www.patreon.com/thatchemist Join the Community Discord! - https://discord.gg/thatchemist *Team* Writer/Producer - That Chemist (Joey) Editor/Lead Animator - ReformLabs 3D Systems Engineer - Robot Chicken Thumbnail Artist - RinFroggy *Acknowledgements* Thanks to the people on Twitter who helped suggest cubane references! Especially Kitspiroplatin for the reference of the extremely long tetracubane iodide! I also want to acknowledge that Tom will eventually make cubane. *References* Tom’s Cubane Series https://www.youtube.com/playlist?list=PLnafk93vhO36cccP0p83hcop3xBTYkoTN Perfluorocubane https://www.youtube.com/watch?v=Tn9EANWD96s Chemiolis Click Chem https://www.youtube.com/watch?v=Ekbqix9fKXQ Casual Chemistry Click Chem https://www.youtube.com/watch?v=RqA4xQ4ujWI Cubane Review Articles: Cubanes in Med Chem http://doi.org/10.1021/acs.jmedchem.8b00888 Cubanes: 50 Years Later http://doi.org/10.1021/cr500523x Bicubyl https://pubs.acs.org/doi/10.1021/ja983441f bidentate cubane ligand https://doi.org/10.1055/s-0029-1217083 butter cubane https://doi.org/10.1016/S0040-4039(00)73295-3 carboxycubane thioxanthylglycine - https://worldwide.espacenet.com/patent/search?q=pn%3DWO2004024709 (page 48) cubane carboxylic acid https://doi.org/10.1002/chem.201901086 cubane dicarboxylic acid dimethyl ester https://doi.org/10.1055/s-0040-1705964 cubane https://doi.org/10.1055/s-1995-3961 cubene https://doi.org/10.1021/ja00229a057 cubyl phenyl ketone https://pubs.rsc.org/en/content/articlelanding/2019/OB/C9OB01238A cubyl triflate https://pubs.acs.org/doi/abs/10.1021/ja00164a063 cubylmethanol https://doi.org/10.1021/ol501750k dideuterocubane https://pubs.acs.org/doi/10.1021/jp953432i diethynyl cubane https://pubs.acs.org/doi/abs/10.1021/ja00096a016 diflucuburon https://doi.org/10.1002/anie.201510675 letepricube https://worldwide.espacenet.com/patent/search?q=pn%3DWO2011068881 mercury cubane insanity https://doi.org/10.1021/cr500523x (compound 71) methoxycarbonylcubane carboxylic acid - 10.1002/chem.201901086 octamethylcubane https://doi.org/10.1016/S0040-4039(00)73295-3 octacyclopropylcubane https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.200605150 octanitrocubane https://doi.org/10.1002/(SICI)1521-3773(20000117)39:2%3C401::AID-ANIE401%3E3.0.CO;2-P (this DOI sucks) octaphenylcubane https://pubs.acs.org/doi/abs/10.1021/jo01058a537 perfluorocubane https://doi.org/10.1126/science.abq0516 perfluorooctamethylcubane https://pubs.acs.org/doi/abs/10.1021/ja00430a050 tetracarbomethoxycubane https://link.springer.com/article/10.1007/BF01665973 tetrabromotetranitrocubane https://pubs.acs.org/doi/10.1021/jo971308k pedestal - https://doi.org/10.1002/anie.199214211 Molecules in this Tierlist Bicubyl, bidentate cubane ligand, butter cubane, carboxycubane thioxanthylglycine, cubane carboxylic acid, cubane dicarboxylic acid dimethyl ester, cubane, cubene, cubyl phenyl ketone, cubyl triflate, cubylmethanol, dideuterocubane, diethynyl cubane, diflucuburon, letepricube, mercury cubane insanity, methoxycarbonylcubane carboxylic acid, octamethylcubane, octacyclopropylcubane, octanitrocubane, octaphenylcubane, perfluorocubane, perfluorooctamethylcubane, tetrabromotetranitrocubane, tetracarbomethoxycubane, tin cubane insanity, extremely long cubane, lead cubane insanity