Erasing Fears & Traumas Using Modern Neuroscience | Huberman Lab Essentials

Andrew Huberman November 6, 2025
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Andrew Huberman

@hubermanlab

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The Huberman Lab podcast is hosted by Andrew Huberman, Ph.D., a neuroscientist and tenured professor in the department of neurobiology of ophthalmology, and by courtesy, psychiatry and behavioral sciences at Stanford School of Medicine. The podcast discusses neuroscience and science-based tools, including how our brain and its connections with the organs of our body control our perceptions, our behaviors, and our health, as well as existing and emerging tools for measuring and changing how our nervous system works.

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In this ⁠Huberman Lab Essentials⁠ episode, I explore the neuroscience of fear and trauma and how to effectively process and eliminate traumatic responses. I explain why successful fear treatment requires both extinction of the old fearful response and replacement with a new positive association—not just cognitive reframing. I also explain how the threat reflex activates specific circuits connecting the amygdala, prefrontal cortex, and dopamine systems, and why detailed recounting of traumatic events progressively reduces their physiological impact. Finally, I review evidence-based approaches, including prolonged exposure therapy and cognitive behavioral therapy, discuss how five minutes per day of deliberate stress through cyclic hyperventilation can rewire fear responses, explain the critical role of social connection in activating neural pathways that reduce trauma, and share supplementation options for managing anxiety. Episode show notes: https://go.hubermanlab.com/WeEXeyX Huberman Lab Essentials are short episodes focused on essential science and protocol takeaways from past full-length Huberman Lab episodes. Watch the full-length episode: https://youtu.be/31wjVhCcI5Y Watch more Huberman Lab Essentials episodes: https://youtube.com/playlist?list=PLPNW_gerXa4OGNy1yE-W9IX-tPu-tJa7S *Follow Huberman Lab* Instagram: https://www.instagram.com/hubermanlab Threads: https://www.threads.net/@hubermanlab X: https://twitter.com/hubermanlab Facebook: https://www.facebook.com/hubermanlab TikTok: https://www.tiktok.com/@hubermanlab LinkedIn: https://www.linkedin.com/in/andrew-huberman Website: https://www.hubermanlab.com Newsletter: https://www.hubermanlab.com/newsletter *Timestamps* 00:00:00 Introducing Fear & Trauma 00:00:17 What is Fear? 00:01:03 Autonomic Arousal: "Alertness" vs. "Calmness" 00:02:05 Fear vs. Stress & Anxiety 00:07:51 "The Threat Reflex": Neural Circuits for Fear 00:17:49 Cognitive (Narrative) Therapies for Fear 00:23:34 PTSD Treatments: Ketamine, MDMA, Oxytocin 00:28:30 Deliberate Brief Stress Can Erase Fears & Trauma 00:31:10 Nutrition, Sleep, & Other General Support Erasing Fear & Trauma 00:33:38 Recap #HubermanLab #Science #Neuroscience Disclaimer & Disclosures: https://www.hubermanlab.com/disclaimer

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