I’m Starting to Worry about Artificial Sweeteners.

Physionic October 2, 2025
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Physionic

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Detailed multi-study analyses, clear explanations of mechanisms underlying the results, and a sprinkling of cheeky humor. Learn your body, from the macro to the micro - welcome to Physionic. Credentials: - Ph.D. in Molecular Medicine (Cell Physiology) - Masters in Exercise Physiology - 10 Years Experience in Laboratory Work - Previous American College of Sports Medicine Certification - Non-Degree in Nutrition Science (1.5 years undergraduate education) - Classroom Professor (T.A. in 2015) in Health, Nutrition, and Physiology since 2016 Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

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*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]* Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2 *HEALTH AUTONOMY [COURSE]* Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy *JOIN THE COMMUNITY* Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2 *EMAIL LIST* 1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6 *HIRE ME FOR CONSULTING:* Consulting: https://bit.ly/3dmUl2H Erythritol and Heart Disease Video: https://youtu.be/tyW5GWZVpmA?si=BoC59ATgRmHwMmrU Created with Biorender 0:00 - Introduction 0:32 - Sweeteners and Declining Brain Health 2:52 - Why I'm Worried... 6:18 - Main Points/Key Takeaways References [Study 522] Gonçalves NG, Martinez-Steele E, Lotufo PA, et al. Association Between Consumption of Low-and No-Calorie Artificial Sweeteners and Cognitive Decline: An 8-Year Prospective Study. ​ Neurology. 2025;105:e214023. doi:10.1212/WNL.0000000000214023. Funding/Conflicts: No Funding / No direct Conflicts of Interest [A] McGlynn ND, Khan TA, Wang L, et al. Association of Low- and No-Calorie Sweetened Beverages as a Replacement for Sugar-Sweetened Beverages With Body Weight and Cardiometabolic Risk: A Systematic Review and Meta-analysis. JAMA Netw Open. 2022;5(3):e222092. Published 2022 Mar 1. doi:10.1001/jamanetworkopen.2022.2092 [B] Spiers PA, Sabounjian L, Reiner A, Myers DK, Wurtman J, Schomer DL. Aspartame: neuropsychologic and neurophysiologic evaluation of acute and chronic effects. Am J Clin Nutr. 1998;68(3):531-537. doi:10.1093/ajcn/68.3.531 [C] Lapierre KA, Greenblatt DJ, Goddard JE, Harmatz JS, Shader RI. The neuropsychiatric effects of aspartame in normal volunteers. J Clin Pharmacol. 1990;30(5):454-460. doi:10.1002/j.1552-4604.1990.tb03485.x [D] Lindseth GN, Coolahan SE, Petros TV, Lindseth PD. Neurobehavioral effects of aspartame consumption. Res Nurs Health. 2014;37(3):185-193. doi:10.1002/nur.21595 [E] Sucralose reduced cognitive function vs sucrose: López-Meza MS, Otero-Ojeda G, Estrada JA, Esquivel-Hernández FJ, Contreras I. The impact of nutritive and non-nutritive sweeteners on the central nervous system: preliminary study. Nutr Neurosci. 2022;25(8):1623-1632. doi:10.1080/1028415X.2021.1885239 [F] Maben AL, Smith AP. Sugar, aspartame and mental performance: a preliminary investigation. Hum Psychopharmacol Clin Exp. 1996;11(1):21-23. ********CRITIQUES, RULES, AND NOTES******** Be aware of the following rules before posting comments: - Please do not post summaries of the video in the comments - it damages retention on the video and YouTube is less likely to promote it (these videos cost me a lot of money to produce). Critiques of my work are welcome! Please be aware of the following notes & rules before submitting critique: Be mindful that this content is not all encompassing on the subject at hand and is self-limited for brevity to reach a wider audience. Also, be aware that I receive hundreds of YouTube comments per day, so the only way your critique can be considered is if you follow the steps outlined below. Finally, YouTube auto-deletes links, so I do not see most comments with links attached. RULES: If your comment is rude, you will be banned. If your comment is not about the studies/topics at hand (i.e. extending to other outcomes not discussed) or offers critique with no scientific basis, it is unlikely to receive a response. If you can follow these rules, I will try to address your critique and if there is merit, I will add an AMENDMENT to the content in question and pin it so everyone can see it (thank you!). Please use the following link to submit your critique: https://bit.ly/PhysionicCritique Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

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