Peter Lidsky | Why Do We Age? Searching for a Paradigm

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Apply to join Foresight Biotech & Health Extension program: https://foresight.org/biotech-health-... A group of scientists, entrepreneurs, funders, and institutional allies who cooperate to advance biotechnology to reverse aging and extend human healthspan. This group is sponsored by 100 Plus Capital. http://100pluscap.com/ Foresights Personal Longevity Group Exploring anti-aging methods, monthly virtual meetings, expert discussions, private group for Foresight Patrons. https://foresight.org/personal-longev... Peter Lidsky | Why Do We Age? Searching for a Paradigm Prof. Peter Lidsky received his MS and PhD training in virology at Moscow State University, where his research focused on virus-host interactions in Picornaviruses. He then transitioned to the University of Zurich to develop tools and probes for fluorescent imaging in the Drosophila model. Finally, at the University of California San Francisco (UCSF), he combined his expertise in virology and genetics to build a versatile research program. Notably, at UCSF, he developed the “pathogen control” hypothesis of aging, which forms the foundation of his current research interests.   / peter-lidsky-71997540   His research focuses on the evolution of aging and diseases, with notable publications in journals such as Trends in Ecology and Evolution, Biochemistry (Moscow), and the Proceedings of the National Academy of Sciences of the United States of America (PNAS). His work explores the relationship between infectious diseases and life history theory, as well as the evolutionary aspects of aging and its potential as a pathogen control strategy. Abstract: Aging is an evolutionary paradox. We know that bad things happen to organisms as they age, but what exactly happens and why remains obscure. However, to cure aging, we must know its nature. Like curing every disease, we must know the diagnosis before starting the treatment. Our evolutionary model suggests that aging evolved as an adaptive mechanism to control the spread of pathogens. The pathogen control model of aging is based on trivial assumptions, can explain aging-related phenomena much better than the classic model, and according to epistemological criteria, it should be considered a priority hypothesis. I will discuss our progress in producing testable predictions to test the model. I will also discuss our work on the "immune militia" hypothesis of cellular senescence, which considers it an antiviral mechanism. Timecodes 00:00 Introduction and Welcome 00:31 The Importance of Aging Research 01:19 Challenges in Aging Research 02:51 Defining Aging and Its Paradigms 04:40 Rejuvenation Debate and Aging Models 08:18 Evolutionary Perspectives on Aging 13:37 Programmed Aging Hypothesis 14:27 Adaptive Death and Pathogen Control 21:00 Testing Evolutionary Theories 25:54 Cellular Senescence and Antiviral Defense 29:31 Interferon Pathway and Senescent Cells 30:20 Immune Militia Model of Cellular Senescence 31:59 Q&A: Programmed Aging Theory vs Non-Programmed 36:33 Debate on Antagonistic Pleiotropy 45:04 Discussion on Experimental Techniques and Lab Work 50:38 Final Thoughts and Concluding Remarks ══════════════════════════════════════ About The Foresight Institute The Foresight Institute is a research organization and non-profit that supports the beneficial development of high-impact technologies. Since our founding in 1986 on a vision of guiding powerful technologies, we have continued to evolve into a many-armed organization that focuses on several fields of science and technology that are too ambitious for legacy institutions to support. From molecular nanotechnology, to brain-computer interfaces, space exploration, cryptocommerce, and AI, Foresight gathers leading minds to advance research and accelerate progress toward flourishing futures. We are entirely funded by your donations. If you enjoy what we do please consider donating through our donation page: https://foresight.org/donate/ Visit https://foresight.org, subscribe to our channel for more videos or join us here: • Twitter:   / foresightinst   • Facebook:   / foresightinst   • LinkedIn:   / foresight-institute