The Golden Age of Genomics

Video Description

Genomics has progressed at a jaw-dropping rate over the last decades. Sequencing devices can reads millions of DNA base pairs. Analysis software and computers are faster than ever. And databases contain an immense number of genome annotations that document how DNA works. In this video, we'll go over the main steps of a whole-genome sequencing project to learn how scientists uncover the workings of our genome, and how bioinformatics algorithms are programmed. Source code for the algorithms: https://github.com/Vincent-Therrien/genome-101/blob/main/tutorial.ipynb Script: https://vincent-therrien.github.io/videos/genomics/script_en.html References: https://vincent-therrien.github.io/videos/genomics/script_en.html#references Fun fact: the opening animation is to scale! I took a real subsequence from human chromosome 13 and resized the characters to make them occupy the right area. The animation does not display *all* 3.1 billion characters of the reference genome because it would have fried my computer, so it blurs out after a few seconds. But it gives you an idea of how massive the genome is. Chapters: - 00:00 Introduction - 00:42 Sequencing - 04:44 Assembly - 08:39 Structural Annotation - 12:05 Functional Annotation - 14:30 Conclusion