The most exciting REAL anti-ageing drugs

Video Description

Find out more about real anti-aging drugs in my book, _Ageless: The new science of getting older without getting old_ https://ageless.link/ Or watch more longevity videos in my playlist: https://youtube.com/playlist?list=PLg0VbZ0kyCHmO8iGdXdg_FudrWauf48BT *Chapters* 00:00 Introduction 00:46 Rapamycin 02:34 Senolytics 04:49 Metformin 06:18 Taurine 07:24 Statins 09:54 Conclusion *Sources and further reading* If you want to know more about rapamycin, @mkaeberlein’s video is a longer introduction to the science behind it https://youtu.be/hwO2Re0MU7k And, if you want to know _much_ more about metformin (and a bunch of other cool longevity science), you might enjoy Nir Barzilai’s interview with @TheProofWithSimonHill https://youtu.be/3faXNaDzrS4 _Rapamycin_ Review of the evidence for rapamycin, rapalogues and other mTOR inhibitors in humans https://www.sciencedirect.com/science/article/pii/S246850112030002X Phase 2b and Phase 3 trials of rapamycin-like drugs for improving immunity in older people https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(21)00062-3/fulltext _Senolytics_ 2018 paper giving D+Q to old mice https://www.nature.com/articles/s41591-018-0092-9 A great overview of the dozens of companies currently working on senolytics https://www.nature.com/articles/s41587-020-00750-1 _Metformin_ Study showing people with diabetes taking metformin outlived ‘healthy’ controls https://dom-pubs.onlinelibrary.wiley.com/doi/10.1111/dom.12354 _Taurine_ More information and links in my Twitter thread on the results https://twitter.com/statto/status/1667075657874939907 The paper (sadly paywalled) https://www.science.org/doi/10.1126/science.abn9257 _Statins_ Effect of statins on all-cause mortality in adults: a systematic review and meta-analysis https://www.mdpi.com/2077-0383/11/19/5643 _General_ A recent paper from the Interventions Testing Program (ITP), with an overview of its successes so far: ‘Six compounds have thus far produced significant extension of life span in ITP studies in 1 or both sexes: rapamycin, 17α-estradiol (17aE2), nordihydroguaiaretic acid (NDGA), Protandim, glycine, and acarbose.’ (This paper adds Canagliflozin to the list.) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7710304/ Here’s the ITP paper on NR, a compound related to NMN and other NAD boosters often discussed by David Sinclair, Harvard professor and author of the book Lifespan https://onlinelibrary.wiley.com/doi/full/10.1111/acel.13328 Calculations for risk of diseases with age can be found at https://github.com/ajsteele/ageless Oh and btw, I’m British so I normally spell it ‘ageing’ just in case anyone’s searching for ‘anti-ageing’. Some people call this field of science biogerontology, geroscience or longevity research. *Credits* Stent animation CC-BY BVM Medical https://commons.wikimedia.org/wiki/File:Stenting_of_Coarctation_of_the_Aorta_using_a_NuMed_CP_Stent_-_BVM_Medical.webm Mice on a treadmill CC-BY Aderbal Aguiar https://www.youtube.com/watch?v=PxH0SBjteuc Atherosclerosis progression diagram CC-BY YitzhakNat https://commons.wikimedia.org/wiki/File:Artery_with_atherosclerosis_progression.png Neutrophil diagram CC0 Mrmw https://commons.wikimedia.org/wiki/File:NeutrophilerAktion.svg *And finally…* Follow me on Twitter https://twitter.com/statto Follow me on Instagram https://www.instagram.com/andrewjsteele Like my page on Facebook https://www.facebook.com/DrAndrewSteele Follow me on Mastodon https://mas.to/@statto Read my book, _Ageless: The new science of getting older without getting old_ https://ageless.link/