We'll Pay $101 Million If You Prove You Can Reverse Aging

Video Description

Subscribe to our channel: https://www.youtube.com/@optispan Get Our Newsletter (It's Free): https://www.optispan.life/ Join me for a fascinating conversation with Dr. Jamie Justice, Executive Director of the $101 Million XPRIZE Healthspan. In this podcast, we discuss the world of longevity science, from the ambitious goals of this global competition to the lessons learned from the stalled TAME trial. https://xprize.org/competitions/healthspan Dr. Justice explains how the XPRIZE is structured to find real-world solutions to extend human healthspan. *Chapters:* 00:01:31 - Jamie's Role & The Mission of XPRIZE Healthspan 00:02:29 - What is the XPRIZE Foundation? 00:05:36 - The Genesis of the Healthspan Prize 00:09:39 - Why Commercial Success Matters for the Prize 00:10:51 - How to Win: The Competition Structure & Timeline 00:18:50 - The 3 Key Healthspan Pillars: Cognitive, Physical, and Immune Function 00:22:03 - Clinical Trial Design: Crossover Trials & "Responder" Analysis 00:27:12 - The Types of Teams & Interventions (From Gene Therapy to Public Health) 00:32:06 - Handling "Wild West" Clinics & The Importance of Data Transparency 00:35:02 - How Many Teams Will Make it to the Finals? 00:37:41 - Safety, Ethics, and Regulatory Hurdles 00:43:42 - The FDA's Role and the Challenge of Approving "Aging" Interventions 00:51:18 - The Story of the TAME Trial: Goals, Design, and Why It Stalled 00:58:23 - The Real Reasons TAME Wasn't Funded (NIH Peer Review & More) 01:07:09 - The Future of Large-Scale Aging Trials 01:13:25 - The Good, The Bad, and The "Pheromones": Crazy XPRIZE Submissions 01:16:49 - Breakdown of Finalist Categories: Drugs, Biologics, Supplements, and Multimodal Approaches 01:22:20 - A Companion Prize for Biomarker Discovery 01:27:30 - The Problem with "Biological Age" and Epigenetic Clocks 01:31:44 - The Ethics of Using Direct-to-Consumer Age Tests in Clinics *About XPRIZE:* XPRIZE's mission is to inspire and empower humanity to achieve breakthroughs that accelerate an equitable, abundant future. Website: https://www.xprize.org/ Get Involved: https://www.xprize.org/get-involved LinkedIn: https://www.linkedin.com/company/x-prize-foundation/ YouTube: https://www.youtube.com/xprize X: http://x.com/xprize Instagram: https://www.instagram.com/xprize/ TikTok: http://tiktok.com/@xprize Facebook: http://facebook.com/xprize This video was produced by One Billion Media, an agency that specializes in YouTube virality for health brands and experts. Learn more about their work here: https://onebillionmedia.com/ DISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices. *More places to find us:* Twitter: https://x.com/Optispan_Inc Twitter: https://x.com/mkaeberlein Linkedin: https://www.linkedin.com/company/optispan/ Instagram: https://www.instagram.com/optispan_/ TikTok: https://www.tiktok.com/@optispan https://www.optispan.life/ 🔬 Discover how teams worldwide are competing to prove they can reverse human aging by 10+ years, and why the winner might not be a drug at all. Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it. On this podcast I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these episodes helpful!