類風濕性關節炎的治療目標 風濕會客室

香港風濕病基金會 HKARF April 7, 2022
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嘉賓講者:香港風濕病基金會副主席暨風濕病科專科醫生吳錦鴻醫生 類風濕性關節炎被介定為一種慢性關節炎,其病徵會維持多於六星期。患者通常會出現關節腫痛,其中以手部最受影響,包括手肘、手腕及肩膀 ;下肢如膝蓋、腳掌和腳眼等亦會遭受對稱性關節影響。患者在早上起床時經常會出現手指關節繃緊的晨僵現象。類風濕性關節炎的成因是自身免疫系統出現毛病,侵襲自己的關節。吳醫生指出基因、家族病史及吸煙人士會較大機會患上類風濕性關節炎。據統計,每四位病人中有三位是女性。一般而言,任何年齡人士都有機會患上此疾病。 治療方法可分為藥物治療和非藥物治療兩種。非藥物治療主要是物理治療、職業治療及水療。而藥物治療主要包括服用消炎藥、傳統抗風濕藥物、生物製劑及口服標靶藥物服用。服用消炎藥只能減輕痛楚,並不能幫助改善病情。而服用傳統抗風濕藥物則有效改善病情,但需定期檢查以了解其可引起的副作用。此外,生物製劑現時已有接近十款藥物,如點滴注射及皮下注射,同時近年亦開始推出口服標靶藥物來抑制免疫系統發炎的物質。 在治療指引上,「DAS 28指數」為衡量病情的標準。首先風濕科醫生會檢查患者28個關節中,有觸痛及腫脹的關節數目,再透過抽血檢測身體的「ESR紅血球沉降率」或「C反應蛋白(CRP)」等發炎指數。同時,配合患者的自我評估,以計算出病情的指數。 若「DAS28」指數高於5.1,代表病情活躍,發炎指數偏高。若指數介乎3.2至5.1之間則為中度活躍。若指數介乎2.6至3.2,病情屬低度活躍。如指數低於2.6,意旨臨床緩解。吳醫生指現時的藥物,如生物制劑及口服標靶藥可以幫助患者達到臨床緩解。若患者能夠持續維持2.6或以下的指數,可避免關節繼續受侵蝕或出現腫痛,患者可維持正常的生活。 吳醫生補充,類風濕性關節炎的黃金治療期為半年至一年內。因此適切的診斷及治療方法尤為重要 。不少病友在剛發病時,誤以為是普通關節炎及腰酸背痛,以致錯過了黃金治療期。他們的關節不但會腫痛,發炎物質還會破壞關節周遭的軟性組織、軟骨、跟腱及韌帶等。一旦關節被破壞或骨質被侵蝕,它們便不可復原。嚴重者,骨質會被侵蝕致變形。故患者應盡早求醫。 28/9/2021

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