Dr. Seyfried and Dr. Dom D'Agostino reveal hard truths about cancer

Video Description

Dr. Seyfried and Dr. Dom D'Agostino reflect on the origin of the press pulse therapeutic strategy, the detailed workings of glioblastoma, and how evolutionary biology is consistent with ketogenic metabolic therapy. Dr. D'Agostino reveals some of his own blood markers and how he thinks about and manages them in his own life. Timestamps: 1:42: When did Dr. Seyfried and Dom begin collaborating? 3:42: Cancer cells produce high ROS and die at high pressures of O2 4:52: Oxygen-stress from hyperbaric O2 therapy could kill cancer cells 7:10: The Press-Pulse strategy 10:32: Combined therapy: keto diet, keto supplements and HBOT 12:17: The VM-M3 mice model for researching metastatic brain cancer 15:20: Keto and combined therapies' potential for metastatic cancer treatment 16:52: The physiology of ketone metabolic therapy 20:07: Cell environment acidification inhibits most cancer therapies 23:32: Versatility of keto diet therapy 27:19: Push-back on keto diets, and thoughts on LDL cholesterol 34:17: Metabolic homeostasis 35:38: Mitochondrial health and cancer as a metabolic disease 37:16: Dom lives in ketosis and spent 10 days underwater 39:07: Ketosis' positive effects on mental health 42:52: Dom and Seyfried's lab test their diets and GKIs 45:44: GKI and disease prevention 46:32: Strategies to optimize keto for individual needs 49:47: GKI and diet varies person by person 51:12: Ketosis' promise for disease prevention 56:39: The cancer field's misconceptions show progress 1:00:28: FAQ 1: Are any clinics offering ketogenic metabolic therapy to patients? 1:08:52: Every major cancer ferments and is susceptible to KMT 1:11:32: FAQ 2: Is there a bias from the NIH in funding this research? 1:13:29: Epigenetic factors and ketone metabolic therapy 1:17:38: Antiparasitic drugs and KMT in cancer Papers mentioned in the order they appear in the video: Blog: Dom's research at USF: https://hscweb3.hsc.usf.edu/blog/2015/12/15/deep-dive-usf-research-combats-oxygen-toxicity-in-navy-divers/ Dr. Seyfried's earlier work using ketogenic diet to target brain cancer: https://pubmed.ncbi.nlm.nih.gov/20009300/ Dr. Seyfried and Dr. D'Agostino's paper on keto with hyperbaric oxygen therapy (HBOT) for targeting cancer: https://pubmed.ncbi.nlm.nih.gov/23755243/ Dr. Seyfried and Dr. D'Agostino's paper on the Press-Pulse protocol: https://pubmed.ncbi.nlm.nih.gov/28250801/ Combined keto diet, keto supplementation and HBOT: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0127407 Metabolic management for the acidic cell environment in GBM: https://pubmed.ncbi.nlm.nih.gov/36059707/ Cancer as a metabolic disease: https://pubmed.ncbi.nlm.nih.gov/24343361/ The Warburg Hypothesis paper: https://pubmed.ncbi.nlm.nih.gov/40199815/ Dr. Jeff Volek's paper (mentioned by Dom for showing keto diet's ability to aid in mental health): https://pmc.ncbi.nlm.nih.gov/articles/PMC11944661/ Antiparasitic drugs and keto for cancer: Dr. Seyfried's preprint article: https://www.biorxiv.org/content/10.1101/2023.06.09.544252v1 For those curious: Read about Dr. D'Agostino's research on seizures here: https://pubmed.ncbi.nlm.nih.gov/30604923/ Read about Dr. Seyfried's earlier work on keto for epilepsy here: https://pubmed.ncbi.nlm.nih.gov/12859666/ Some of the notable quotes from Dr. Seyfried during this conversation:  "We can cure type 2 diabetes with metabolic therapies and get rid of hypertension. A lot of neuropsychiatric problems can be managed with nutritional ketosis, even dementia. Most dementias are the result of metabolic inhomeostasis. Ultimately this all comes down to mitochondrial health. Mitochondrial dysfunction is the underlying pathological process of all of these diseases, including cancer. Cancer is a mitochondrial metabolic disorder."  "A large problem is getting this information into the clinics. When you talk to oncologists they have never heard of almost anything we're discussing. Medical students in the medical schools are not getting any information about managing chronic illness with metabolic therapies." "We have never found a person with cancer who has healthy mitochondria" Follow Dr. Seyfried on X: https://x.com/tnseyfried Follow Dr. Seyfried on Instagram: https://www.instagram.com/thomasseyfriedbc/ Follow Dr. D'Agostino on X: https://x.com/DominicDAgosti2 Follow Dr. D'Agostino on Instagram: https://www.instagram.com/dominic.dagostino.kt/ Read the most recent research published by Dr. Seyfried's Lab: https://link.springer.com/article/10.1007/s10863-025-10059-w