85: How Autophagy Protects Your Cells and Boosts Longevity with Dr. Ben Bikman

Video Description

In this Metabolic Classroom lecture, Dr. Bikman delves into the fascinating metabolic process of autophagy, the body’s natural recycling system that maintains cellular health by breaking down and reusing damaged components. Ben explains how autophagy is essential for replacing malfunctioning organelles and proteins, thereby preventing diseases such as neurodegenerative disorders, cardiovascular conditions, and even some cancers. Autophagy also plays a crucial role in energy production during nutrient deprivation, highlighting its importance for survival and optimal cellular function. Dr. Bikman also discusses the relationship between autophagy and metabolic health, emphasizing how impaired autophagic activity in adipose tissue contributes to inflammation and insulin resistance in obesity. He explores its role in longevity, citing evidence that enhanced autophagy can improve health span and lifespan in animal studies. Additionally, Ben examines how factors like insulin, nutrient availability, and diets such as ketogenic diets regulate autophagy, with ketones having a direct effect on boosting this process. Throughout the lecture, Dr. Bikman underscores the need for balance in autophagy, warning against excessive or constant activation, whether through pharmacological means like rapamycin or mismanaged dietary habits, advocating instead for natural regulation via nutrient signals. Show Notes/References: For complete show notes and references referred to in this episode, we invite you to become a Ben Bikman Insider subscriber. As a subscriber, you’ll enjoy real-time, livestream Metabolic Classroom access which includes live Q&A with Ben, ad-free Metabolic Classroom Podcast episodes, show notes and references, Ben’s Research Reviews Podcast, and a searchable archive that includes all Metabolic Classroom episodes and Research Reviews. Learn more about becoming an Insider on our website: https://www.benbikman.com (Auto-Translate Note: You can click the gear icon at the bottom of this video to auto-translate captions. For example, to translate into Polish, select Subtitles, choose Auto-Translate, then first choose English, then choose Auto-Translate again, then choose Polish.) Timestamps: 01:44 - What is Autophagy? A Cellular Perspective 05:28 - Role of Autophagy in Energy Production During Fasting 07:41 - Autophagy’s Connection to Obesity and Metabolic Health 12:05 - Autophagy and Longevity: Insights from Research 14:34 - Rapamycin, mTOR, and the Risks of Pharmacological Interventions 17:07 - Insulin’s Role in Autophagy Regulation 20:00 - How Low-Carb and Ketogenic Diets Enhance Autophagy 24:10 - Balancing Anabolism and Catabolism for Optimal Health 26:35 - Conclusion: The Natural Regulation of Autophagy Ben’s favorite yerba maté and fiber supplement: https://ufeelgreat.com/usa/en/c/1BA884 Ben’s favorite meal-replacement shake: https://gethlth.com (discount: BEN10) Ben’s favorite electrolytes (and more): https://redmond.life (discount: BEN15) Ben’s favorite allulose source: https://rxsugar.com (discount: BEN20) Ben’s favorite health check-up for women: https://choosejoi.co/drben15 (discount: DRBEN15) Ben’s favorite health check-up for men: https://blokes.co/drben15 (discount: DRBEN15) Ben’s favorite exogenous ketone: https://www.americanketone.com (discount: Ben10) Other products Ben likes: https://www.amazon.com/shop/benbikmanphd #Autophagy #MetabolicHealth #Longevity #KetogenicDiet #CellularHealth #BenBikman #MetabolicClassroom #InsulinResistance #NutrientSignals #FastingBenefits #HealthyAging #Mitochondria #CellularRecycling #Ketones #LowCarbDiet #HealthOptimization #MetabolismMatters #LysosomeFunction #HealthyLongevity Learn more about becoming an Insider on our website: https://www.benbikman.com