Aminoglycosides | Clinical Uses and Adverse effects 💊

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#drnajeeb #pharmacology #aminoglycosides #antibiotics Aminoglycosides | Clinical Uses and Adverse effects Like this video? Sign up now on our website at https://www.DrNajeebLectures.com to access 1000+ Exclusive videos on Basic Medical Sciences & Clinical Medicine. These are premium videos (NOT FROM YOUTUBE). All these videos come with English subtitles & download options. Sign up now! Get Lifetime Access for a one-time payment of $59 ONLY! Sign up now on our website at https://members.drnajeeblectures.com/ --------------------------------------------------------------------------------------------------------------------------- Why sign up for premium membership? Here's why! Membership Features for premium website members. 1. More than 1000+ Medical Lectures. 2. Basic Medical Sciences & Clinical Medicine. 3. Mobile-friendly interface with android and iOS apps. 4. English subtitles and new videos every week. 5. Download option for offline video playback. 6. Fanatic customer support and that's 24/7. 7. Fast video playback option to learn faster. 8. Trusted by over 2M+ students in 190 countries. --------------------------------------------------------------------------------------------------------------------------- ▬▬▬▬▬▬▬▬▬▬ Contents of this video ▬▬▬▬▬▬▬▬▬▬ 00:00:00 Aminoglycosides are Toxic drugs to be used cautiously 00:00:26 Major toxicities of Aminoglycoside 00:03:32 Adverse affect :Ototoxicity 00:05:19 Adverse affect :Nephrotoxicity 00:07:37 Adverse affect :Paralysis 00:08:30 Avoid in Pregnant women 00:09:33 Topical administration is safer 00:10:43 High dose extended interval regimen 00:11:48 Adverse affect of Nephrotoxicity is reversible while ototoxicity is irreversible 00:13:06 synergictic use of Aminoglycosides and its advantages 00:13:55 Clinical uses of Aminoglycosides 00:14:58 Aminoglycoside use in neonatal meningitis and sepsis. 00:16:35 Aminoglycoside use in pulmonary infections including pneumonia and abscess 00:17:25 Difference between nectrotizing pneumonia and pulmonary abscess . 00:18:50 Cystic fibrosis infections involve pseudomanas aeroginosa organism 00:20:49 Aminoglycoside use in infective endocarditis 00:25:00 List of infections above the diaphragm for which Aminoglycosides are used. 00:25:30- Use of Aminoglycosides for prophylaxis and infections below diaphragm. 00:26:40 Neomycin use in hepatic encephalopathy 00:29:05 Review of clinical uses of aminoglycoside. 00:30:02 Use in Bone and joint conditions 00:30:40 Use in skin and soft tissue infections 00:31:35 Aminoglycoside only used as monotherapy The aminoglycoside class of antibiotics consists of many different agents. In the United States, gentamicin, tobramycin, amikacin, plazomicin, streptomycin, neomycin, and paromomycin are approved by the US Food and Drug Administration (FDA) and are available for clinical use. Of these, gentamicin, tobramycin, and amikacin are the most frequently prescribed by intramuscular or intravenous injection for systemic treatment. The most common clinical application (either alone or as part of combination therapy) of the aminoglycosides is for the treatment of serious infections caused by aerobic gram-negative bacilli. While less common, aminoglycosides (in combination with other agents) have also been used for the treatment of select gram-positive infections. In addition, certain aminoglycosides have demonstrated clinically relevant activity against protozoa (paromomycin), Neisseria gonorrhoeae (spectinomycin, not available in the United States), and mycobacterial infections (tobramycin, streptomycin, and [most commonly] amikacin). This topic will review basic issues related to the clinical use of parenteral aminoglycosides, including mechanism of action, spectrum of activity, and adverse effects. Dosing and monitoring of aminoglycosides and administration in certain patient populations are discussed elsewhere.  --------------------------------------------------------------------------------------------------------------------------- Join this channel to get access to the perks: Sign up now on our website at https://members.drnajeeblectures.com/ Follow us on Facebook:- https://www.facebook.com/DrNajeeb/ Follow us on Instagram:- https://www.instagram.com/drnajeeblectures/