The New Skinny on Lp(a)

Video Description

For references, extra nuances and my Lp(a) protocol, see this letter: https://staycuriousmetabolism.substack.com/p/why-lpa-may-not-be-as-dangerous-as?r=40ekz2 Relevant Prior Videos Lp(a) Background Video: https://youtu.be/iVwDJqJiTEY Lp(a) and Vitamin C Video: https://youtu.be/3rbJnKnhg3s MPO Video: https://youtu.be/inTK-9DCxf0 Lipoprotein(a), or Lp(a), is one of the most feared genetic risk factors for heart disease. But new 2025 data tell a far more hopeful story. In this video, I break down a large, long-term study showing that Lp(a)-related cardiovascular risk depends heavily on metabolic context, especially waist-to-hip ratio — a simple marker of visceral fat. Shockingly, in people with low waist-to-hip ratios, even high Lp(a) levels were not associated with increased heart disease risk. We walk through the data, the graphs, the mechanisms (clotting, inflammation, oxidative stress), and the practical takeaways. Genes are not destiny. Metabolic health changes the story. Chapters 0:00 – I Have Lp(a)… Oh No! 1:47 – New Study on Waist-to-Hip Ratio and Lp(a) 2:47 – High Lp(a) But Low WHR… Low Risk! 3:31 – Look At This Graph! 4:28 – And Now Look at These Graphs! 5:45 – Your Waist-to-Hip Ratio Goals 7:23 – Mechanisms: Why Would Waist-to-Hip Ratio Matter for Lp(a) Risk? 10:11 – Teasing the Protocol… See More at StayCurious Metabolism 11:00 – Summarizing Key Points #LpA #HeartHealth #CardiovascularDisease #Genetics #MetabolicHealth #VisceralFat #WaistToHipRatio #Atherosclerosis #Inflammation #OxidativeStress #PrecisionHealth #Longevity #HealthScience #PreventiveCardiology #NickNorwitz #StayCurious