69: Leaky Gut Explained - Dr. Ben Bikman on Gut Health and Inflammation

Video Description

Learn more about becoming an Insider on my website: https://www.benbikman.com In this episode of The Metabolic Classroom, Dr. Ben Bikman explores the topic of leaky gut syndrome, explaining how substances enter the body through the intestines and how the gut acts as a controlled gateway. While nutrients like amino acids, glucose, and fats are transported through the intestinal lining via a process called transcellular transport, problems arise when the tight junctions between the cells weaken. This can lead to harmful substances, including large molecules and microbes, passing into the bloodstream in a process known as paracellular transport. A key player in leaky gut syndrome is the molecule lipopolysaccharide (LPS), which comes from certain gut bacteria. Under normal conditions, LPS stays in the intestines and is expelled with waste, but when it enters the bloodstream due to leaky gut, it can trigger a chronic inflammatory response. This inflammation is linked to conditions like obesity, heart disease, and fatty liver disease. Bikman emphasized that even low levels of LPS in the blood can promote insulin resistance, further contributing to metabolic disorders. Several dietary and environmental factors can compromise the integrity of the gut barrier. Ben highlights the negative impact of fructose, which weakens tight junction proteins and promotes oxidative stress. Polyunsaturated fats from refined seed oils and gluten, especially in people with sensitivities, can also increase intestinal permeability. Additionally, chronic stress and alcohol consumption were identified as contributors to leaky gut. On a positive note, Dr. Bikman discusses strategies to improve gut health, such as consuming short-chain fatty acids (like butyrate), found in dairy and certain fibers. He also mentioned the potential benefits of saturated fats, particularly from dairy, which may promote gut healing. Lastly, Dr. Bikman shares the role of LDL cholesterol as a “scavenger” that helps remove harmful LPS from the blood, suggesting its misunderstood importance in immune health. https://www.insuliniq.com 00:00 Introduction to Leaky Gut 01:52 How Substances Enter the Body Through the Gut 03:58 Structure and Function of the Gut Lining 07:07 Normal Transport vs. Leaky Gut Transport 09:23 The Role of LPS in Leaky Gut and Inflammation 11:41 How LPS Affects the Body 12:45 Low-Grade Systemic Inflammation 15:23 Cardiometabolic Consequences of Leaky Gut 18:52 Dietary Triggers of Leaky Gut: Fructose and Seed Oils 22:14 The Impact of Gluten and Stress on Gut Health 24:05 Strategies to Improve Gut Health 25:09 Short Chain Fatty Acids and Saturated Fats for Gut Healing 28:08 The Role of LDL Cholesterol in Gut Health 31:16 The Importance of Fiber and Probiotics 33:32 The Rare Sugar Allulose and Gut Integrity 35:23 Conclusion and Practical Takeaways My favorite meal-replacement shake: https://gethlth.com (discount: BEN10) My favorite electrolytes (and more): https://redmond.life (discount: BEN15) My favorite allulose source: https://rxsugar.com (discount: BEN20) References: Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid-induced ceramide biosynthesis in mice: https://pubmed.ncbi.nlm.nih.gov/21490391/ Linking Gut Microbiota and Inflammation to Obesity and Insulin Resistance: https://www.semanticscholar.org/paper/Linking-Gut-Microbiota-and-Inflammation-to-Obesity-Saad-Santos/1561c519bc7325fe1035f872b626720f56d90064 Impacts of Fructose on Intestinal Barrier Function, Inflammation and Microbiota in a Piglet Model: https://www.semanticscholar.org/paper/Impacts-of-Fructose-on-Intestinal-Barrier-Function,-Guo-Wang/6f81e8f7998bcb6f9fa6a948cd048392a42bc374 Glucose but Not Fructose Alters the Intestinal Paracellular Permeability in Association With Gut Inflammation and Dysbiosis in Mice: https://www.semanticscholar.org/paper/Glucose-but-Not-Fructose-Alters-the-Intestinal-in-Zhang-Monnoye/b567cdeb7fa1f335f296a8047cddd2b9980b232f Fructose Promotes Leaky Gut, Endotoxemia, and Liver Fibrosis Through Ethanol‐Inducible Cytochrome P450‐2E1–Mediated Oxidative and Nitrative Stress: https://www.semanticscholar.org/paper/Fructose-Promotes-Leaky-Gut,-Endotoxemia,-and-Liver-Cho-Kim/5c2092d035f326f65b8dd2d48b3a99a6beceae40 Allulose enhances epithelial barrier function by tight junction regulation via the TLR4/MyD88/NF-κB immune signaling pathway in an intestinal Caco-2 cell model: https://www.sciencedirect.com/science/article/pii/S1756464623003213 #LeakyGut #GutHealth #Inflammation #InsulinResistance #LPS #DrBenBikman #MetabolicHealth #NutritionScience #GutHealing #HealthTips #Fructose #SaturatedFat #Probiotics #LDLCholesterol #ShortChainFattyAcids #MetabolicClassroom #GlutenSensitivity #SeedOils #Prebiotics #HealthyGut