SIBO, Histamine & the Vagus Nerve

Dr. Michael Ruscio, DC, DNM July 7, 2025
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Dr. Michael Ruscio, DC, DNM

@drrusciodc

About

Dr. Ruscio Radio is hosted by Dr. Michael Ruscio, DC, DNM, a functional medicine clinician and researcher specializing in gut health, autoimmune disease, thyroid disorders, and chronic illness. This channel breaks down functional medicine research into clear, practical steps to help you heal—without the bias and the noise. Rooted in published clinical research, our work focuses on the gut as the foundation of health and its impact on immunity, hormones, and brain function. Topics include: - Gut health: SIBO, IBS, GERD, candida & parasites - Autoimmune & thyroid conditions (Hashimoto’s, Graves’) - Histamine intolerance, mast cell activation & immune health - Lyme, mold illness & chronic infections - Brain-gut health: brain fog, anxiety, depression & insomnia If you want science-backed functional medicine guidance you can trust, you’re in the right place.

Video Description

Today I’m happy to chat with our patient Leslie who shares her successful journey with histamine intolerance healing. We’ll go through how SIBO led to her histamine issues, the connection to low vagus nerve tone, as well as the low histamine diet and treatments such as dao enzymes. Tune in to learn how you can reduce histamine in the body naturally. Start healing with us! Learn more about our virtual clinic: https://drruscio.com/virtual-clinic/ Download the free Histamine Intolerance and Diet Guide: https://drruscio.com/guides/get-histamine-intolerance-guide/ 💊 Products used in Leslie’s protocol: ✅Quercetin: 🔹3 capsules, 1-3 times per day. https://store.drruscio.com/products/quercetin?variant=39556224778437 ✅Resveratrol 500mg Ultra High Potency: 🔹1 capsule twice daily, may increase to 2 capsules twice daily https://store.drruscio.com/products/resveratrol?variant=39555978494149 ✅Vitamin C with Bioflavonoids : 🔹1-2 tsp or 2 capsules, 1-3x per day https://store.drruscio.com/products/vitamin-c?variant=39591130595525 ✅Histamine Digest (DAO enzyme): 🔹1 prior to meals, may increase to 2 prior to meals https://store.drruscio.com/products/histamine-digest?variant=42174647435461 ✅Intestinal Support Formula (ISF): 🔹5 grams of Immunoglobulin per serving 🔹Dose range: 5-10 grams per day. 2 scoops = 5 grams. 🔹May be taken with or without food. 🔹Research shows between 5-10 grams per day to be beneficial https://store.drruscio.com/products/intestinal-support?variant=29051287765044 https://pubmed.ncbi.nlm.nih.gov/24833942/ ✅Probiotic Triple Therapy Sticks: 🔹62 billion CFU per serving 🔹Dose range: 1-3 packets per day 🔹Probiotics may be taken with or without food https://store.drruscio.com/products/triple-therapy-probiotic?variant=40164201922757 ✅Vagus Nerve Stimulation with VaguStim 🔹15-30 minutes 1-2x per day 🔹Follow the user manual and app instructions to get started. 🔹It’s important to ensure you’re using enough conductive gel in the ears for the device to work effectively. If you’re only noticing a faint sensation, even with the device setting fairly high, you’re either not using enough gel or the batteries are low. 🔹It may take up to 1-2 months to observe a benefit from vagus nerve stimulation https://vagustim.io/collections/home/products/vagus-nerve-stimulation-vns-device-for-individuals 🧠Check out our video on vagus nerve stimulation for more information 4 Powerful Vagus Nerve Tools to Rewire Your Nervous System: https://www.youtube.com/watch?v=Adccokcgo0U 👇 Watch more videos like this 👇 ➡️5 Warning Signs You’re Histamine Intolerant: https://www.youtube.com/watch?v=JPBAd9RzIf4 ➡️The Top Diet & Supplements For Healing Histamine Intolerance: https://www.youtube.com/watch?v=stRThUfzfMM Subscribe: https://www.youtube.com/@DrRuscioDC?sub_confirmation=1 Have questions? Let me know in the comments! 👇Read these next 👇 ➡️Vagus Nerve Symptoms, & How to Deal with Them: https://drruscio.com/vagus-nerve-damage-symptoms/ ➡️Everything You Need To Know About Histamine Intolerance: https://drruscio.com/everything-you-need-to-know-about-histamine-intolerance/ Timestamps 00:00 Intro 02:45 SIBO & histamine intolerance signs 07:30 Histamine intolerance protocol 10:57 Low histamine diet 16:14 How intolerance happens 18:24 Gut-brain connection 23:32 Probiotics 25:26 Vagus nerve stimulation 36:21 The importance of mindset 40:31 Key takeaways 41:17 Choosing the right healthcare Featured Studies 📉Biofilm Disruption Enhances Antimicrobial Therapy for SIBO (Dr. Ruscio Clinic): https://pubmed.ncbi.nlm.nih.gov/41394228/ 📉Low Serum Diamine Oxidase Activity & Carbohydrate Malabsorption: https://pubmed.ncbi.nlm.nih.gov/28042564/ 📉Disorders of gut-brain interaction in the US: https://pubmed.ncbi.nlm.nih.gov/36961084/ 📉Probiotics for Allergic Rhinitis: https://pubmed.ncbi.nlm.nih.gov/35663980/ 📉Symptoms and psychological status in IBS: https://pubmed.ncbi.nlm.nih.gov/36178333/ 📉Vagus nerve stimulation & histamine-induced itching: https://pubmed.ncbi.nlm.nih.gov/12105316/ 📉Limbic & temporal brain structures & mood enhancing by vagus nerve stimulation: https://pubmed.ncbi.nlm.nih.gov/17564758/ 📉Transcutaneous Auricular Vagus Nerve Stimulation in IBS-C: https://pubmed.ncbi.nlm.nih.gov/39689011/ 📉Serum-derived bovine immunoglobulin protein isolate in IBS-D https://pubmed.ncbi.nlm.nih.gov/24833942/ Follow Me FB - https://www.facebook.com/DrRuscio IG - https://www.instagram.com/drruscio/ DISCLAIMER: The information on this site is not intended or implied to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified healthcare provider before starting any new treatment or discontinuing an existing treatment. Music featured in this video: "Modern Technology" by Andrew G, https://audiojungle.net/user/andrew_g *Full transcript available on YouTube by clicking the “Show transcript” button on the bottom right of the video.

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